The most common early sign of Lyme disease is a skin rash that has a "bull's eye" appearance. It begins as a reddened area near the tick bite. As the rash increases in size, it clears in the middle and develops a red ring around the outside.
Single bullseye rash
A person may experience multiple rashes, such as you see here. The rash is not caused from multiple tick bites, but occurs as a reaction when the bacteria moves through the body.
This is an example of Lyme arthritis in the knee. Joints may become red, swollen, and painful.